{"id":4575,"date":"2023-11-13T00:46:30","date_gmt":"2023-11-12T16:46:30","guid":{"rendered":"https:\/\/tinapoint.com\/?p=4575"},"modified":"2023-11-13T22:33:15","modified_gmt":"2023-11-13T14:33:15","slug":"clear-bempedoic-acid","status":"publish","type":"post","link":"https:\/\/tinapoint.com\/clear-bempedoic-acid\/","title":{"rendered":"\u3010CLEAR\u3011Statin\u00a0\u7121\u6cd5\u8010\u53d7\u8005\uff0cBempedoic\u00a0acid\u00a0\u53ef\u4e0b\u964d\u91cd\u5927\u5fc3\u8840\u7ba1\u4e8b\u4ef6"},"content":{"rendered":"\n<p>2020 \u5e74\uff0c\u65b0\u6a5f\u8f49\u964d\u8840\u8102\u85e5\u7269 Bempedoic&nbsp;acid \u65bc\u7f8e\u570b FDA \u53d6\u5f97\u8a31\u53ef\u8b49\uff0c\u7531\u65bc\u5176\u7368\u7279\u7684\u6a5f\u8f49\uff0c\u865f\u7a31\u808c\u8089\u526f\u4f5c\u7528\u6bd4 statin \u985e\u85e5\u7269\u5c11\u30022023 \u5e74 4 \u6708\uff0cNEJM \u767c\u8868 CLEAR study \u7d50\u679c\u986f\u793a\uff0c\u5c0d\u65bc statin \u7121\u6cd5\u8010\u53d7\u8005\uff0cBempedoic&nbsp;acid \u53ef\u4ee5\u4e0b\u964d\u91cd\u5927\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\uff0c\u7814\u7a76\u7d50\u679c\u5230\u5e95\u5982\u4f55\uff1f\u8ab0\u5c6c\u65bc statin \u7121\u6cd5\u8010\u53d7\u8005\uff1f\u808c\u8089\u526f\u4f5c\u7528\u771f\u7684\u6709\u6bd4\u8f03\u5c11\u55ce\uff1f\u5feb\u9032\u4f86\u770b\u770b\u5427\uff01<\/p>\n\n\n\n<!--more-->\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_50 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">\u5167\u5bb9\u76ee\u9304<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\" role=\"button\"><label for=\"item-663b77773c8c1\" aria-hidden=\"true\"><span style=\"display: flex;align-items: center;width: 35px;height: 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class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E5%89%8D%E8%A8%80\" title=\"\u524d\u8a00\">\u524d\u8a00<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#Bempedoic_acid%E2%80%8B_%E4%BB%8B%E7%B4%B9\" title=\"Bempedoic acid\u200b \u4ecb\u7d39\">Bempedoic acid\u200b \u4ecb\u7d39<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E5%BF%83%E8%A1%80%E7%AE%A1%E5%A4%A7%E5%9E%8B%E7%A0%94%E7%A9%B6%EF%BC%9ACLEAR_outcome_trial\" title=\"\u5fc3\u8840\u7ba1\u5927\u578b\u7814\u7a76\uff1aCLEAR outcome trial\">\u5fc3\u8840\u7ba1\u5927\u578b\u7814\u7a76\uff1aCLEAR outcome trial<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E6%94%B6%E6%A1%88%E6%97%8F%E7%BE%A4\" title=\"\u6536\u6848\u65cf\u7fa4\">\u6536\u6848\u65cf\u7fa4<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E5%B0%8D_statin_%E9%A1%9E%E8%97%A5%E7%89%A9%E4%B8%8D%E8%80%90%E5%8F%97%E7%9A%84%E5%AE%9A%E7%BE%A9%E7%82%BA%E4%BD%95%EF%BC%9F\" title=\"\u5c0d statin \u985e\u85e5\u7269\u4e0d\u8010\u53d7\u7684\u5b9a\u7fa9\u70ba\u4f55\uff1f\">\u5c0d statin \u985e\u85e5\u7269\u4e0d\u8010\u53d7\u7684\u5b9a\u7fa9\u70ba\u4f55\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E7%A0%94%E7%A9%B6%E6%B5%81%E7%A8%8B\" title=\"\u7814\u7a76\u6d41\u7a0b\">\u7814\u7a76\u6d41\u7a0b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E6%94%B6%E6%A1%88%E7%8B%80%E6%85%8B\" title=\"\u6536\u6848\u72c0\u614b\">\u6536\u6848\u72c0\u614b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E7%A0%94%E7%A9%B6%E7%B5%90%E6%9E%9C\" title=\"\u7814\u7a76\u7d50\u679c\">\u7814\u7a76\u7d50\u679c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E4%B8%8D%E8%89%AF%E4%BA%8B%E4%BB%B6%E9%A2%A8%E9%9A%AA%EF%BC%8C%E8%82%8C%E8%82%89%E5%89%AF%E4%BD%9C%E7%94%A8%E7%9C%9F%E7%9A%84%E6%9C%89%E6%AF%94%E8%BC%83%E4%BD%8E%E5%97%8E%EF%BC%9F\" title=\"\u4e0d\u826f\u4e8b\u4ef6\u98a8\u96aa\uff0c\u808c\u8089\u526f\u4f5c\u7528\u771f\u7684\u6709\u6bd4\u8f03\u4f4e\u55ce\uff1f\">\u4e0d\u826f\u4e8b\u4ef6\u98a8\u96aa\uff0c\u808c\u8089\u526f\u4f5c\u7528\u771f\u7684\u6709\u6bd4\u8f03\u4f4e\u55ce\uff1f<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/tinapoint.com\/clear-bempedoic-acid\/#%E7%B5%90%E8%AA%9E\" title=\"\u7d50\u8a9e\">\u7d50\u8a9e<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%89%8D%E8%A8%80\"><\/span><strong>\u524d\u8a00<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u6700\u8fd1\u5ee0\u5546\u696d\u52d9\u4f86\u627e\u6211\uff0c\u60f3\u8a62\u554f\u6211\u5011\u91ab\u9662\u95dc\u65bc phase 4 trial \u7d50\u675f\u5f8c\uff0c\u5982\u4f55\u8b93\u75c5\u4eba\u53ef\u4ee5\u7e7c\u7e8c\u958b\u7acb\u8a72\u85e5\u54c1\u3002<\/p>\n\n\n\n<p>\u5148\u8aaa\u660e\u4e00\u4e0b\uff0cphase 4 \u6307\u7684\u662f\u85e5\u54c1\u4e0a\u5e02\u5f8c\u7684\u8ffd\u8e64\uff0c\u6536\u96c6\u5927\u91cf\u75c5\u4eba\u9032\u884c\u9577\u6642\u9593\u300c\u89c0\u5bdf\u300d\uff0c\u76e3\u6e2c\u8a72\u85e5\u7269\u662f\u5426\u6709\u5148\u524d\u5e7e\u500b\u968e\u6bb5\u6c92\u767c\u73fe\u7684\u526f\u4f5c\u7528\u6216\u662f\u4e0d\u826f\u53cd\u61c9\u3002<\/p>\n\n\n\n<p>\u6211\u9084\u6eff\u597d\u5947\u662f\u54ea\u500b\u85e5\u7684\uff0c\u4e00\u554f\u4e4b\u4e0b\u767c\u73fe\u662f\u65b0\u6a5f\u8f49\u7684\u964d\u8840\u8102\u85e5\u7269 bempedoic acid\u200b\u3002<\/p>\n\n\n\n<p>\uff08murmur\uff1a\u6316\u54e9\u561e\u53c8\u85e5\u5ff5\u66f8\u4e86&#8230;\u2026\uff09<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/2022-taiwan-lipid-guideline\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u3010TSOC\u30112022\u9ad8\u8840\u8102\u6cbb\u7642\u6307\u5f15\u66f4\u65b0\uff0cLDL\u76ee\u6a19\u4e0b\u4fee\u5566\uff01(\u542b\u5f71\u7247\u8aaa\u660e)<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bempedoic_acid%E2%80%8B_%E4%BB%8B%E7%B4%B9\"><\/span><strong>Bempedoic acid\u200b \u4ecb\u7d39<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Bempedoic acid\u200b\uff0c\u5546\u54c1\u540d Nexletol\uff0c2020 \u5e74\u65bc\u7f8e\u570b FDA \u53d6\u5f97\u8a31\u53ef\u8b49\uff0c\u53ef\u4ee5\u8207 statin \u4f75\u7528\uff0c\u964d\u4f4e LDL-C \u7684\u7570\u5408\u5b50\u5bb6\u65cf\u6027\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff08HeFH\uff09\uff0c\u6216\u5df2\u78ba\u8a3a\u7684\u52d5\u8108\u7ca5\u6a23\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff08ASCVD\uff09\u7684\u6210\u4eba\uff0c\u7528\u6cd5\u70ba 180mg QD PO\uff0c<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"581\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-2-1024x581.jpg\" alt=\"\" class=\"wp-image-4583\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-2-1024x581.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-2-300x170.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-2-768x436.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-2-1170x663.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-2-585x332.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-2.jpg 1278w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Bempedoic acid \u6a5f\u8f49<\/figcaption><\/figure>\n\n\n\n<p>Bempedoic acid\u200b \u548c statin \u7684\u6a5f\u8f49\u6eff\u50cf\u7684\u3002<\/p>\n\n\n\n<p>Statin \u662f\u6291\u5236 HMG-CoA \u9084\u539f\u9176\uff0cBempedoic acid \u200b\u5247\u662f\u6291\u5236\u66f4\u4e0a\u6e38\u7684\u4e09\u78f7\u9178\u817a\u82f7\u6ab8\u6aac\u9178\u88c2\u89e3\u9176\uff08adenosine triphosphate citrate lyase\uff0c\u7c21\u7a31 ACL\uff09\uff0c\u9032\u800c\u964d\u4f4e\u809d\u81df\u4e2d\u81bd\u56fa\u9187\u7684\u5408\u6210\uff0c\u9084\u80fd\u4e0a\u8abf\u809d\u81df\u8868\u9762\u7684 LDL \u53d7\u9ad4\u6578\u91cf\uff0c\u4f7f LDL \u5e36\u56de\u809d\u81df\u7684\u91cf\u589e\u52a0\u200b\uff0c\u9032\u800c\u6e1b\u5c11\u8840\u6db2\u4e2d LDL\u200b\u3002<\/p>\n\n\n\n<p>\u56e0\u70ba Bempedoic acid\u200b \u9700\u8981\u7d93\u904e\u809d\u81df ACSVL1 \u8f49\u5316\u6210\u6d3b\u6027\u6210\u5206\uff0c\u4e0d\u904e\u9aa8\u9abc\u808c\u4e2d\u6c92\u6709 ACSVL1\uff0c\u56e0\u6b64\u6700\u4ee4\u4eba\u671f\u5f85\u7684\u662f\uff0cBempedoic acid \u7684\u9aa8\u9abc\u808c\u526f\u4f5c\u7528\u53ef\u80fd\u6bd4\u8f03\u5c11\u3002<\/p>\n\n\n\n<p>P.S. Statin \u985e\u85e5\u7269\u7522\u751f\u808c\u8089\u75bc\u75db\u526f\u4f5c\u7528\u7d04 10-15%\u3002<\/p>\n\n\n\n<p>2021 \u5e74\u85e5\u5b78\u96dc\u8a8c\u6709\u767c\u8868\u76f8\u95dc\u6587\u7ae0\uff08<strong><span style=\"text-decoration: underline;\"><a href=\"https:\/\/jtp.taiwan-pharma.org.tw\/146\/012.html\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/jtp.taiwan-pharma.org.tw\/146\/012.html\" rel=\"noreferrer noopener\">\u9ede\u6211\u958b\u555f<\/a><\/span><\/strong>\uff09\uff0c\u662f\u4e2d\u6587\u7684\uff0c\u53ef\u4ee5\u5148\u5feb\u901f\u95b1\u8b80\u4e86\u89e3\u4e00\u4e0b\uff5e<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BF%83%E8%A1%80%E7%AE%A1%E5%A4%A7%E5%9E%8B%E7%A0%94%E7%A9%B6%EF%BC%9ACLEAR_outcome_trial\"><\/span><strong>\u5fc3\u8840\u7ba1\u5927\u578b\u7814\u7a76\uff1aCLEAR outcome trial<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>2023 \u5e74 4 \u6708\uff0cNEJM \u767c\u8868\u7684 CLEAR \u7814\u7a76\u986f\u793a\uff0cBempedoic Acid \u7528\u65bc statin \u7121\u6cd5\u8010\u53d7\u8005\uff0c\u53ef\u4ee5\u4e0b\u964d\u91cd\u5927\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\u3002<\/p>\n\n\n\n<p>CLEAR \u662f\u4e00\u500b\u96d9\u76f2\u3001\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u542b 32 \u500b\u570b\u5bb6 1250 \u500b\u5730\u9ede\u7684\u53d7\u8a66\u8005\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-1-1024x576.jpg\" alt=\"\" class=\"wp-image-4582\" style=\"width:712px;height:auto\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-1-1024x576.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-1-300x169.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-1-768x432.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-1-1170x658.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-1-585x329.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-1.jpg 1281w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-font-size is-style-fill has-medium-font-size\"><a class=\"wp-block-button__link has-vivid-cyan-blue-background-color has-background wp-element-button\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36876740\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u9ede\u6211\u958b\u555f CLEAR \u7814\u7a76<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%94%B6%E6%A1%88%E6%97%8F%E7%BE%A4\"><\/span><strong>\u6536\u6848\u65cf\u7fa4<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"580\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-3-1024x580.jpg\" alt=\"\" class=\"wp-image-4577\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-3-1024x580.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-3-300x170.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-3-768x435.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-3-1170x663.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-3-585x331.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-3.jpg 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>18-85 \u6b72\uff0c\u5c0d statin \u4e0d\u8010\u53d7\uff0c\u4e14\u5df2\u6709\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff08secondary prevention\uff09\uff0c\u6216\u9ad8\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\uff08primary prevention\uff09\u8005\u3002<\/p>\n\n\n\n<div class=\"wp-block-group box\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p><strong>\u5df2\u6709\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u8005\uff08secondary prevention\uff09\uff0c\u5b9a\u7fa9\u5982\u4e0b\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>\u51a0\u5fc3\u75c5\uff08Coronary artery disease\uff09<\/li>\n\n\n\n<li>\u6709\u75c7\u72c0\u7684\u5468\u908a\u8840\u7ba1\u75be\u75c5\uff08Symptomatic peripheral arterial disease\uff09<\/li>\n\n\n\n<li>\u8166\u8840\u7ba1\u75be\u75c5\uff08Cerebrovascular atherosclerotic disease\uff09<\/li>\n\n\n\n<li>\u4ee5\u4e0a\u75be\u75c5\u9808\u767c\u751f\u65bc\u7be9\u9078\u524d 90 \u5929\uff0c\u592a\u63a5\u8fd1\u7684\u4e0d\u6703\u6536\u6848<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group box\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p><strong>\u9ad8\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\u8005\uff08primary prevention\uff09\uff0c\u5b9a\u7fa9\u5982\u4e0b\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>Reynolds Risk score &gt;30%<\/li>\n\n\n\n<li>SCORE Risk score &gt;7.5% over 10 years<\/li>\n\n\n\n<li>\u904e\u53bb\u4efb\u4f55\u6642\u9593\u9ede Coronary artery calcium score &gt;400 Agatston units (AU)<\/li>\n\n\n\n<li>\u6709\u7b2c\u4e00\u578b\u6216\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5<\/li>\n\n\n\n<li>\u5973\u6027\u5e74\u9f61 \uff1e 65 \u6b72\uff0c\u7537\u6027\u5e74\u9f61 \uff1e 60 \u6b72<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u672c\u7814\u7a76\u6392\u9664 eGFR\uff1c30 mL\/min\/1.73 m^2\u3001\u7a7a\u8179\u4e09\u9178\u7518\u6cb9\u916f\uff1e500mg\/dL\u3001HbA1C\uff1e10%\u3001AST \u6216 ALT \u5927\u65bc\u6b63\u5e38\u4e0a\u9650 2 \u500d\u3001HBsAg \u6216 HCV antibodies \u967d\u6027\u3001Hgb\uff1c10g\/dL \u7b49\u65cf\u7fa4\u3002<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B0%8D_statin_%E9%A1%9E%E8%97%A5%E7%89%A9%E4%B8%8D%E8%80%90%E5%8F%97%E7%9A%84%E5%AE%9A%E7%BE%A9%E7%82%BA%E4%BD%95%EF%BC%9F\"><\/span><strong>\u5c0d statin \u985e\u85e5\u7269\u4e0d\u8010\u53d7\u7684\u5b9a\u7fa9\u70ba\u4f55\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"has-vivid-red-color has-text-color has-link-color wp-elements-5a8c6f34e123a6b38c8e4e2ba1d3418c\">Statin \u985e\u85e5\u7269\u525b\u958b\u59cb\u7528\uff0c\u6216\u5617\u8a66\u589e\u52a0\u5291\u91cf\u6642\uff0c\u53d7\u8a66\u8005\u51fa\u73fe\u4e0d\u826f\u53cd\u61c9\uff0c\u4e14 statin \u505c\u7528\u5f8c\u6539\u5584\uff0c\u5247\u5b9a\u7fa9\u70ba statin \u4e0d\u8010\u53d7\uff08\u201cstatin-intolerant\u201d patients\uff09\u3002<\/p>\n\n\n\n<p>\u4e0d\u904e\u672c\u7814\u7a76\u5b9a\u7fa9\u7684 statin \u4e0d\u8010\u53d7\uff0c\u4e5f\u4e0d\u662f\u8aaa\u5b8c\u5168\u4e0d\u80fd\u4f7f\u7528 statin\u3002<\/p>\n\n\n\n<p>\u5c0d\u65bc\u4f7f\u7528\u4f4e\u5291\u91cf statin \u8005\uff0c\u96d6\u7136\u4e0a\u8abf\u5291\u91cf\u6642\u51fa\u73fe\u4e0d\u826f\u53cd\u61c9\u800c\u88ab\u5b9a\u7fa9\u70ba statin \u4e0d\u8010\u53d7\uff0c\u4f46\u7814\u7a76\u671f\u9593\u9084\u662f\u53ef\u4ee5\u7e7c\u7e8c\u4f7f\u7528\u4f4e\u5291\u91cf statin\uff0c\u7d04\u4f54\u672c\u7814\u7a76\u65cf\u7fa4\u7684 22-23%\u3002<\/p>\n\n\n\n<div class=\"wp-block-group list\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p><strong>\u4f4e\u5291\u91cf statin \u7684\u5e73\u5747\u65e5\u5291\u91cf\u5b9a\u7fa9\u5982\u4e0b\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>rosuvastatin &lt;5 mg<\/li>\n\n\n\n<li>atorvastatin &lt;10 mg<\/li>\n\n\n\n<li>simvastatin &lt;10 mg<\/li>\n\n\n\n<li>lovastatin &lt;20 mg<\/li>\n\n\n\n<li>pravastatin &lt;40 mg<\/li>\n\n\n\n<li>fluvastatin &lt;40 mg<\/li>\n\n\n\n<li>pitavastatin &lt;2 mg<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E6%B5%81%E7%A8%8B\"><\/span><strong>\u7814\u7a76\u6d41\u7a0b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u9032\u5165\u70ba\u671f 4 \u9031\u7684\u78e8\u5408\u671f\uff0c\u5728\u6b64\u671f\u9593\u6703\u63a5\u53d7\u55ae\u76f2\u5b89\u6170\u5291\u3002\u5982\u679c\u60a3\u8005\u56e0\u4e0d\u53ef\u63a5\u53d7\u7684\u4e0d\u826f\u53cd\u61c9\u800c\u7121\u6cd5\u7e7c\u7e8c\u7528\u85e5\uff08\u5b89\u6170\u5291\uff09\uff0c\u6216\u6839\u64da\u7247\u5291\u8a08\u6578\uff0c\u670d\u85e5\u914d\u5408\u5ea6\u4f4e\u65bc 80% \u8005\uff0c\u88ab\u8996\u70ba\u4e0d\u7b26\u5408\u96a8\u6a5f\u5206\u7d44\u7684\u8cc7\u683c\u800c\u6392\u9664\u3002<\/p>\n\n\n\n<p>\u6210\u529f\u5b8c\u6210\u78e8\u5408\u671f\u7684\u53d7\u8a66\u8005\uff0c\u4ee5 1:1 \u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u914d\uff0c\u63a5\u53d7\u6bcf\u65e5\u53e3\u670d\u5291\u91cf 180 mg \u7684 Bempedoic Acid \u6216\u5b89\u6170\u5291\u3002<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%94%B6%E6%A1%88%E7%8B%80%E6%85%8B\"><\/span><strong>\u6536\u6848\u72c0\u614b<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>2016\/12 \u81f3 2019\/8 \u671f\u9593\uff0c\u5171\u6709 13,970 \u540d\u60a3\u8005\u63a5\u53d7\u4e86\u96a8\u6a5f\u5206\u7d44\uff1b6992 \u4eba\u88ab\u5206\u914d\u5230 bempedoic Acid \u7d44\uff0c6978 \u4eba\u88ab\u5206\u914d\u5230\u5b89\u6170\u5291\u7d44\u3002<\/p>\n\n\n\n<p>\u5169\u7d44\u53d7\u8a66\u8005\u7684 baseline \u76f8\u4f3c\uff0c\u5e73\u5747\u5e74\u9f61\u70ba 65.5 \u6b72\uff0c\u5973\u6027\u4f54 48.2%\uff0c45.6% \u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c69.9% \u66fe\u767c\u751f\u904e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff0c22.7% \u670d\u7528 statin \u985e\u85e5\u7269\uff0c11.5% \u670d\u7528 ezetimibe\uff0c\u8ffd\u8e64\u6642\u9593\u4e2d\u4f4d\u6578\u70ba 40.6 \u500b\u6708\u3002<\/p>\n\n\n\n<p>\u6536\u6848\u6642 LDL-C \u5e73\u5747\u503c\u70ba 139 mg\/dL\uff0cHDL \u5e73\u5747\u503c\u70ba 49.5 mg\/dL\uff0c\u4e09\u9178\u7518\u6cb9\u916f\u4e2d\u4f4d\u6578\u70ba 159 mg\/dL\uff0chigh-sensitivity CRP \u4e2d\u4f4d\u6578\u70ba 2.3 mg\/L\u3002<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E7%B5%90%E6%9E%9C\"><\/span><strong>\u7814\u7a76\u7d50\u679c<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"580\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-52-1024x580.jpg\" alt=\"\" class=\"wp-image-4588\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-52-1024x580.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-52-300x170.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-52-768x435.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-52-1170x663.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-52-585x331.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-52.jpg 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-vivid-red-color has-text-color has-link-color wp-elements-603edca2e9a4bfd810fe12f0cbda8bbd\">Bempedoic Acid \u7d44\u6709 11.7% \u53d7\u8a66\u8005\u767c\u751f\u4e3b\u8981\u4e8b\u4ef6\u7d42\u9ede\uff08\u5fc3\u56e0\u6027\u6b7b\u4ea1\u3001\u975e\u81f4\u547d\u6027\u5fc3\u808c\u6897\u585e\u3001\u975e\u81f4\u547d\u6027\u4e2d\u98a8\u6216\u51a0\u72c0\u52d5\u8108\u8840\u904b\u91cd\u5efa\uff0c\u56db\u9805\u4efb\u4e00\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba 13.3%\uff0cHR=0.87\uff0c\u5177\u6709\u986f\u8457\u597d\u8655\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u7684\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u70ba\u5fc3\u56e0\u6027\u6b7b\u4ea1\u3001\u975e\u81f4\u547d\u6027\u5fc3\u808c\u6897\u585e\u6216\u975e\u81f4\u547d\u6027\u4e2d\u98a8\u4e09\u9805\u4efb\u4e00\uff08\u4e5f\u5c31\u662f\u6392\u9664\u6700\u5f8c\u4e00\u500b\uff0c\u51a0\u72c0\u52d5\u8108\u8840\u7ba1\u91cd\u5efa\uff09\uff0cbempedoic Acid \u4e5f\u662f\u5177\u6709\u986f\u8457\u597d\u8655\u3002<\/p>\n\n\n\n<p>\u55ae\u7368\u770b\u5fc3\u808c\u6897\u585e\u3001\u51a0\u72c0\u52d5\u8108\u8840\u7ba1\u91cd\u5efa\uff0cbempedoic Acid \u4ecd\u5177\u6709\u986f\u8457\u597d\u8655\u3002<\/p>\n\n\n\n<p>\u4e0d\u904e\u4e2d\u98a8\u3001\u5fc3\u56e0\u6027\u6b7b\u4ea1\u3001\u5168\u56e0\u6027\u6b7b\u4ea1\u9019\u4e09\u500b\u7814\u7a76\u7d42\u9ede\u5c31\u6c92\u6709\u986f\u8457\u5dee\u7570\u4e86\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"580\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-4-1024x580.jpg\" alt=\"\" class=\"wp-image-4578\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-4-1024x580.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-4-300x170.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-4-768x435.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-4-1170x663.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-4-585x331.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-4.jpg 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"has-vivid-red-color has-text-color has-link-color wp-elements-eebacf0cb085289066f4b938ffc094f7\">LDL-C \u964d\u5e45\u7684\u90e8\u5206\uff0cbempedoic acid \u7d44\u4f7f\u7528\u7d04 3 \u500b\u6708\u7684\u6642\u9593\uff0c\u5c31\u53ef\u4ee5\u770b\u5230 LDL-C \u4e0b\u964d 20% \u4ee5\u4e0a\uff0c\u4e14\u6301\u7e8c\u4f7f\u7528 60 \u500b\u6708\u6548\u679c\u4ecd\u53ef\u7dad\u6301\uff0c\u4ee5\u6536\u6848\u6642 LDL-C \u5e73\u5747\u503c\u70ba 139 mg\/dL\uff0c\u9810\u4f30\u53ef\u4ee5\u964d\u4f4e\u81f3 111 mg\/dL\u3002<\/p>\n\n\n\n<p>P.S. \u4e0d\u904e CV \u9ad8\u98a8\u96aa\u8005\u7684 LDL-C \u76ee\u6a19\u503c\u8981\uff1c70mg\/dL\uff0c\u611f\u89ba\u9084\u662f\u4e0d\u592a\u5920\uff0c\u53ef\u80fd\u9084\u8981\u642d\u914d ezetimibe \u6216 PCSK9i\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u53e6\u5916\u6709\u89c0\u5bdf\u5230\uff0chigh-sensitivity CRP \u5728\u516d\u500b\u6708\u5f8c\u53ef\u4ee5\u964d\u4f4e\u7d04 20%\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u5728 Discussion \u6709\u63d0\u5230\uff0cstatin \u985e\u85e5\u7269\u4e5f\u53ef\u4ee5\u964d\u4f4e high-sensitivity CRP\uff0c\u4f46 PCSK9i \u548c ezetimibe \u7684\u55ae\u4e00\u6cbb\u7642\u537b\u6c92\u6709\u770b\u5230\u767c\u708e\u76f8\u95dc\u7684\u751f\u7269\u6a19\u8a18\u6e1b\u5c11\uff0c\u9019\u4e5f\u53ef\u80fd\u8aaa\u660e statin \u985e\u85e5\u7269\u8207 bempedoic acid \u5c0d\u5fc3\u8840\u7ba1\u75be\u75c5\u4e0b\u964d\u7684\u984d\u5916\u597d\u8655\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%B8%8D%E8%89%AF%E4%BA%8B%E4%BB%B6%E9%A2%A8%E9%9A%AA%EF%BC%8C%E8%82%8C%E8%82%89%E5%89%AF%E4%BD%9C%E7%94%A8%E7%9C%9F%E7%9A%84%E6%9C%89%E6%AF%94%E8%BC%83%E4%BD%8E%E5%97%8E%EF%BC%9F\"><\/span><strong>\u4e0d\u826f\u4e8b\u4ef6\u98a8\u96aa\uff0c\u808c\u8089\u526f\u4f5c\u7528\u771f\u7684\u6709\u6bd4\u8f03\u4f4e\u55ce\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u4e0d\u826f\u4e8b\u4ef6\u6574\u9ad4\u767c\u751f\u7387\u5728 bempedoic Acid \u7d44\u548c\u5b89\u6170\u5291\u7d44\u4e4b\u9593\u6c92\u6709\u986f\u8457\u5dee\u7570\u3002<\/p>\n\n\n\n<p>\u56e0\u4efb\u4f55\u539f\u56e0\uff08\u5305\u62ec\u4e0d\u826f\u808c\u8089\u9aa8\u9abc\u5f71\u97ff\uff09\u800c\u505c\u85e5\u7684\u767c\u751f\u7387\uff0cBempedoic acid \u8207\u5b89\u6170\u5291\u76f8\u4f3c\uff0c\u5169\u7d44\u90fd\u5927\u7d04 10-11%\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"580\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-62-1024x580.jpg\" alt=\"\" class=\"wp-image-4589\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-62-1024x580.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-62-300x170.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-62-768x435.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-62-1170x663.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-62-585x331.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/11\/CLEAR-bempedoic-acid-62.jpg 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-group box\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p><strong>\u500b\u5225\u4e8b\u4ef6\u4e2d\uff0cBempedoic acid \u6709\u4e94\u9805\u4e0d\u826f\u4e8b\u4ef6\u7684\u767c\u751f\u7387\u8f03\u9ad8\uff1a<\/strong><\/p>\n\n\n\n<ul>\n<li>\u809d\u9175\u7d20\u6c34\u5e73\u5347\u9ad8\uff084.5% vs. 3.0%\uff09<\/li>\n\n\n\n<li>\u814e\u81df\u4e8b\u4ef6\uff0811.5% vs. 8.6%\uff09<\/li>\n\n\n\n<li>\u9ad8\u5c3f\u9178\u8840\u75c7\uff0810.9% vs. 5.6%\uff09<\/li>\n\n\n\n<li>\u75db\u98a8\uff083.1% vs. 2.1%\uff09<\/li>\n\n\n\n<li>\u81bd\u77f3\u75c7\uff082.2% vs. 1.2%\uff09<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u5148\u524d\u7814\u7a76\u7684\u78ba\u6709\u767c\u73fe\uff0cbempedoic acid \u7d44\u4e2d\u89c0\u5bdf\u5230\u814e\u5c0f\u7ba1\u5c3f\u9178\u548c\u808c\u9178\u9150\u6392\u6cc4\u6e1b\u5c11\uff0c\u56e0\u6b64\u9ad8\u5c3f\u9178\u8840\u75c7\u548c\u75db\u98a8\u7684\u767c\u751f\u7387\u8f03\u9ad8\uff0c\u503c\u5f97\u6ce8\u610f\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u81f3\u65bc\u6211\u5011\u8ce6\u4e88\u773e\u671b\u7684\u808c\u8089\u75db\u6709\u6bd4\u8f03\u5c11\u55ce\uff1f<\/p>\n\n\n\n<p class=\"list\"><strong>Bempedoic Acid \u7d44\u4e2d 5.6% \u7684\u53d7\u8a66\u8005\u51fa\u73fe\u808c\u75db\uff0c\u5b89\u6170\u5291\u7d44\u4e2d\u9019\u4e00\u6bd4\u4f8b\u70ba 6.8%\uff0c\u56e0\u808c\u8089\u75db\u800c\u505c\u6b62\u7528\u85e5\u5206\u5225\u70ba 1.8% \u8207 1.9%\uff0c\u770b\u4f3c\u6bd4\u8f03\u5c11\uff0c\u4f46\u5dee\u8ddd\u4e5f\u4e0d\u5927<\/strong>\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u5176\u4ed6\u9810\u5148\u6307\u5b9a\u7684\u7279\u5225\u95dc\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6\u7684\u767c\u751f\u7387\uff0c\u5305\u62ec\u65b0\u767c\u7cd6\u5c3f\u75c5\u6216\u60e1\u5316\u3001\u4f4e\u8840\u7cd6\u548c\u4ee3\u8b1d\u6027\u9178\u4e2d\u6bd2\u3001\u795e\u7d93\u8a8d\u77e5\u969c\u7919\u3001\u5fc3\u623f\u986b\u52d5\u3001\u808c\u8171\u75c5\uff08\u5305\u62ec\u808c\u8171\u65b7\u88c2\uff09\u548c\u60e1\u6027\u75be\u75c5\uff0c\u5728\u5169\u7d44\u4e4b\u9593\u6c92\u6709\u986f\u8457\u5dee\u7570\u3002<\/p>\n\n\n\n<p>\u9ad8\u5f37\u5ea6 statin \u53ef\u80fd\u589e\u52a0\u65b0\u767c\u7cd6\u5c3f\u75c5\u98a8\u96aa\uff0c\u4e0d\u904e\u672c\u7814\u7a76\u986f\u793a\uff0cbempedoic Acid \u4e0d\u6703\u589e\u52a0\u7cd6\u5316\u8840\u7d05\u7d20\u6c34\u5e73\u6216\u65b0\u767c\u7cd6\u5c3f\u75c5\u7684\u767c\u751f\u7387\u3002<\/p>\n\n\n\n<p>P.S.\u4f46\u5176\u5be6\u5fc3\u5167\u91ab\u5e2b\u4e0d\u592a\u6703\u5728\u610f\u65b0\u767c\u7cd6\u5c3f\u75c5\u9019\u4ef6\u4e8b\uff0c\u56e0\u70ba statin \u5c31\u662f\u53ef\u4ee5\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u98a8\u96aa\uff0c\u9019\u624d\u662f\u6700\u91cd\u8981\u7684\uff0c\u4e14\u904e\u53bb\u7814\u7a76\u986f\u793a\uff0cstatin \u4e3b\u8981\u662f\u81e8\u9580\u4e00\u8173\uff0c\u4e5f\u5c31\u662f\u9019\u7fa4\u4eba\u672c\u4f86\u5c31\u5c6c\u65bc\u7cd6\u5c3f\u75c5\u524d\u671f\u4e86\uff0c\u53ea\u662f\u9ad8\u5f37\u5ea6 statin \u7a0d\u5fae\u52a0\u901f\u9019\u500b\u904e\u7a0b\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/empa-kidney\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u3010EMPA-KIDNEY\u3011EMPAGLIFLOZIN&nbsp;10MG \u5c0d CKD \u65cf\u7fa4\u6709\u826f\u597d\u5fc3\u814e\u4fdd\u8b77\u6548\u679c<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%90%E8%AA%9E\"><\/span><strong>\u7d50\u8a9e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CLEAR \u7814\u7a76\u986f\u793a\uff0cBempedoic Acid \u7528\u65bc statin \u7121\u6cd5\u8010\u53d7\u8005\uff0c\u8ffd\u8e64\u7d04 3 \u5e74\u7684\u6642\u9593\uff0c\u53ef\u4ee5\u4e0b\u964d 13% \u91cd\u5927\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\uff0c\u964d\u4f4e LDL-C \u7d04 22%\uff0c\u56e0\u808c\u8089\u75db\u800c\u505c\u6b62\u7528\u85e5\u5927\u7d04 2%\u3002<\/p>\n\n\n\n<p>\u4f46\u9700\u8981\u6ce8\u610f\u809d\u814e\u529f\u80fd\u3001\u75db\u98a8\u3001\u8207\u81bd\u7d50\u77f3\u98a8\u96aa\uff0c\u5c24\u5176\u662f\u9ad8\u5c3f\u9178\u8840\u75c7\u98a8\u96aa\u7d04 11%\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/guideline-list\/\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/tinapoint.com\/guideline-list\/\" rel=\"noreferrer noopener\">\u3010\u4e0d\u65b7\u66f4\u65b0\u3011\u5fc3\u8840\u7ba1\u75be\u75c5\u6cbb\u7642\u6307\u5f15\u4e00\u89bd\u8868<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group box\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\u4f60\u662f\u91ab\u9662\u85e5\u5e2b\u6216\u8b77\u7406\u5e2b\u55ce\uff1f<\/p>\n\n\n\n<p>\u6642\u5e38\u9047\u5230\u75c5\u4eba\u8981\u7d66\u8a31\u591a\u91dd\u5291\u85e5\u54c1\uff0c\u7919\u65bc\u7ba1\u8def\u4e0d\u5920\u9700\u8981\u540c\u6642\u7d66\u85e5 &#8230;&#8230;<\/p>\n\n\n\n<p>\u537b\u4e0d\u77e5\u9053\u9019\u4e9b\u85e5\u7269\u53ef\u4e0d\u53ef\u4ee5\u65c1\u63d2\u4f7f\u7528\u55ce\uff1f<\/p>\n\n\n\n<p>\u5225\u64d4\u5fc3\uff01<\/p>\n\n\n\n<p>\u5c0f\u6db5\u85e5\u5e2b\u6574\u7406\u4e86\u4f4f\u9662\u75c5\u4eba\u5e38\u7528\u7684\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\uff0c\u6b61\u8fce\u9ede\u64ca\u4e0b\u5716\u7d22\u53d6\u5594\uff01<\/p>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/subscribepage.io\/EPTKCz\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-1024x574.png\" alt=\"\" class=\"wp-image-3721\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-1024x574.png 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-300x168.png 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-768x431.png 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-585x328.png 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716.png 1038w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/subscribepage.io\/o1gTEc\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" width=\"1024\" height=\"573\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-1024x573.png\" alt=\"\" class=\"wp-image-3722\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-1024x573.png 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-300x168.png 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-768x430.png 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-585x327.png 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716.png 1038w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>2020 \u5e74\uff0c\u65b0\u6a5f\u8f49\u964d\u8840\u8102\u85e5\u7269 Bempedoic acid \u65bc\u7f8e\u570b FDA \u53d6\u5f97\u8a31\u53ef\u8b49\uff0c\u7531\u65bc\u5176\u7368\u7279\u7684\u6a5f\u8f49\uff0c\u865f\u7a31\u808c\u8089\u526f\u4f5c\u7528\u6bd4 statin \u985e\u85e5\u7269\u5c11\u30022023 \u5e74 4 \u6708\uff0cNEJM \u767c\u8868 CLEAR study \u7d50\u679c\u986f\u793a\uff0c\u5c0d\u65bc statin \u7121\u6cd5\u8010\u53d7\u8005\uff0cBempedoic acid \u53ef\u4ee5\u4e0b\u964d\u91cd\u5927\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\uff0c\u7814\u7a76\u7d50\u679c\u5230\u5e95\u5982\u4f55\uff1f\u8ab0\u5c6c\u65bc statin \u7121\u6cd5\u8010\u53d7\u8005\uff1f\u808c\u8089\u526f\u4f5c\u7528\u771f\u7684\u6709\u6bd4\u8f03\u5c11\u55ce\uff1f\u5feb\u9032\u4f86\u770b\u770b\u5427\uff01<\/p>\n","protected":false},"author":1,"featured_media":4581,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[106],"tags":[125,74,126],"table_tags":[],"modified_by":"\u5c0f\u6db5\u85e5\u5e2b","_links":{"self":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/4575"}],"collection":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/comments?post=4575"}],"version-history":[{"count":2,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/4575\/revisions"}],"predecessor-version":[{"id":4597,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/4575\/revisions\/4597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/media\/4581"}],"wp:attachment":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/media?parent=4575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/categories?post=4575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/tags?post=4575"},{"taxonomy":"table_tags","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/table_tags?post=4575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}