{"id":4536,"date":"2023-10-30T10:00:00","date_gmt":"2023-10-30T02:00:00","guid":{"rendered":"https:\/\/tinapoint.com\/?p=4536"},"modified":"2023-10-30T09:50:27","modified_gmt":"2023-10-30T01:50:27","slug":"empa-kidney","status":"publish","type":"post","link":"https:\/\/tinapoint.com\/empa-kidney\/","title":{"rendered":"\u3010EMPA-KIDNEY\u3011Empagliflozin\u00a010mg \u5c0d CKD \u65cf\u7fa4\u6709\u826f\u597d\u5fc3\u814e\u4fdd\u8b77\u6548\u679c"},"content":{"rendered":"\n<p>2023\/1\/12 EMPA-KIDNEY \u7814\u7a76\u767c\u8868\uff0c\u8a55\u4f30 Empagliflozin 10mg QD \u5c0d\u814e\u81df\u75be\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u9032\u5c55\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u672c\u85e5\u5728 CKD \u65cf\u7fa4\u4e2d\u7684\u5b89\u5168\u6027\uff0c\u7d50\u679c\u986f\u793a\u53ef\u4ee5\u986f\u8457\u4e0b<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-black-color\">\u964d\u9996\u6b21\u767c\u751f\u814e\u81df\u60e1\u5316\u6216\u5fc3\u56e0\u6027\u6b7b\u4ea1\u98a8\u96aa\u3002<\/mark>\u672c\u6587\u9084\u6574\u7406\u4e86 SGLT2i \u4fdd\u8b77\u814e\u81df\u7684\u6a5f\u8f49\uff0c\u4ee5\u53ca empagliflozin \u4eff\u55ae\u4fee\u8a02\u5167\u5bb9\uff0c\u5feb\u4f86\u770b\u770b\u5427\uff01<\/p>\n\n\n\n<!--more-->\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_50 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">\u5167\u5bb9\u76ee\u9304<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\" role=\"button\"><label for=\"item-663b74f05158b\" aria-hidden=\"true\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-663b74f05158b\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/tinapoint.com\/empa-kidney\/#%E5%89%8D%E8%A8%80\" title=\"\u524d\u8a00\">\u524d\u8a00<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/tinapoint.com\/empa-kidney\/#%E7%A0%94%E7%A9%B6%E8%A8%AD%E8%A8%88%E8%88%87%E7%B5%90%E6%9E%9C\" title=\"\u7814\u7a76\u8a2d\u8a08\u8207\u7d50\u679c\">\u7814\u7a76\u8a2d\u8a08\u8207\u7d50\u679c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/tinapoint.com\/empa-kidney\/#Empagliflozin_%E5%AE%89%E5%85%A8%E6%80%A7\" title=\"Empagliflozin \u5b89\u5168\u6027\">Empagliflozin \u5b89\u5168\u6027<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/tinapoint.com\/empa-kidney\/#Empagliflozin_%E5%A6%82%E4%BD%95%E6%94%B9%E5%96%84%E8%85%8E%E5%8A%9F%E8%83%BD%EF%BC%9F\" title=\"Empagliflozin \u5982\u4f55\u6539\u5584\u814e\u529f\u80fd\uff1f\">Empagliflozin \u5982\u4f55\u6539\u5584\u814e\u529f\u80fd\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/tinapoint.com\/empa-kidney\/#Empagliflozin_10mg_%E4%BB%BF%E5%96%AE%E4%BF%AE%E8%A8%82%EF%BC%9A%E6%94%BE%E5%AF%AC%E8%85%8E%E5%8A%9F%E8%83%BD%E4%BD%BF%E7%94%A8%E9%99%90%E5%88%B6\" title=\"Empagliflozin 10mg \u4eff\u55ae\u4fee\u8a02\uff1a\u653e\u5bec\u814e\u529f\u80fd\u4f7f\u7528\u9650\u5236\">Empagliflozin 10mg \u4eff\u55ae\u4fee\u8a02\uff1a\u653e\u5bec\u814e\u529f\u80fd\u4f7f\u7528\u9650\u5236<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/tinapoint.com\/empa-kidney\/#%E7%B5%90%E8%AA%9E\" title=\"\u7d50\u8a9e\">\u7d50\u8a9e<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%89%8D%E8%A8%80\"><\/span>\u524d\u8a00<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>2023\/1\/12 EMPA-KIDNEY \u7814\u7a76\u767c\u8868\uff0c\u70ba\u570b\u969b\u3001\u96a8\u6a5f\u3001\u5e73\u884c\u7d44\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u81e8\u5e8a\u8a66\u9a57\uff08international, randomized, parallel-group, double-blind, placebo-controlled, clinical trial\uff09\uff0c\u76ee\u7684\u70ba\u8a55\u4f30 Empagliflozin 10mg QD \u5c0d\u814e\u81df\u75be\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u9032\u5c55\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u672c\u85e5\u5728 CKD \u65cf\u7fa4\u4e2d\u7684\u5b89\u5168\u6027\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2204233\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-1-1024x576.jpg\" alt=\"\" class=\"wp-image-4537\" style=\"aspect-ratio:1.7777777777777777;width:709px;height:auto\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-1-1024x576.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-1-300x169.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-1-768x432.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-1-1170x658.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-1-585x329.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-1.jpg 1281w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"wp-element-caption\">EMPA-KIDNEY trial<\/figcaption><\/figure><\/div>\n\n\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2204233\" target=\"_blank\" rel=\"noreferrer noopener\"><span style=\"text-decoration: underline;\">Ref:\u00a0N Engl J Med.\u00a02023 Jan 12;388(2):117-127.\u200b<\/span><\/a><\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u4e4b\u524d\u6709\u5206\u4eab\u904e empagliflozin \u5728\u5fc3\u81df\u8870\u7aed\u7684\u76f8\u95dc\u7814\u7a76\uff0c\u4e5f\u662f\u4ee5 10mg \u5291\u91cf\u9032\u884c\u7684\uff0825mg \u662f\u7528\u65bc\u7cd6\u5c3f\u75c5\u7684\u5291\u91cf\uff09\u3002<\/p>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/r001\/\">\u3010\u6587\u737b\u5c0e\u8b80\u3011EMPAGLIFLOZIN\u964d\u4f4e\u5fc3\u81df\u8870\u7aed\u75c5\u4eba25%\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\uff0c\u4e0d\u7ba1\u6709\u7121\u7cd6\u5c3f\u75c5(EMPEROR-REDUCED)<\/a><\/strong><\/p>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/r003\/\">\u3010\u6587\u737b\u5c0e\u8b80\u3011\u5fc3\u81df\u8870\u7aed\u91cd\u5927\u7a81\u7834\uff01EMPAGLIFLOZIN\u53ef\u4ee5\u964d\u4f4eHFPEF\u65cf\u7fa4\u7684\u98a8\u96aa(EMPEROR-PRESERVED)<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A0%94%E7%A9%B6%E8%A8%AD%E8%A8%88%E8%88%87%E7%B5%90%E6%9E%9C\"><\/span><strong>\u7814\u7a76\u8a2d\u8a08<\/strong>\u8207\u7d50\u679c<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"575\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-4-1024x575.jpg\" alt=\"\" class=\"wp-image-4543\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-4-1024x575.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-4-300x168.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-4-768x431.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-4-1170x657.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-4-585x328.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-4.jpg 1283w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">EMPA-KIDNEY trial \u7814\u7a76\u8a2d\u8a08\u8207\u7d50\u679c<\/figcaption><\/figure>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>EMPA-KIDNEY trial \u5728 8 \u500b\u570b\u5bb6\u5171 241 \u500b\u4e2d\u5fc3\u9032\u884c\u6536\u6848\uff0c\u6536\u6848\u671f\u9593\u70ba 2019\/2\uff5e2021\/4\u3002<\/p>\n\n\n\n<div class=\"wp-block-group box\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\u7b26\u5408\u4ee5\u4e0b\u5169\u9ede\u4efb\u4e00\uff0c\u5373\u53ef\u9032\u884c\u6536\u6848\uff1a<\/p>\n\n\n\n<ul>\n<li>eGFR 20-45 mL\/min\/1.73^2\uff0c\u4e0d\u7ba1\u6709\u7121\u86cb\u767d\u5c3f<\/li>\n\n\n\n<li>eGFR 45-90 mL\/min\/1.73^2\uff0c\u4e14\u6709\u5de8\u91cf\u86cb\u767d\u5c3f\uff0c\u5c3f\u6db2\u767d\u86cb\u767d\u8207\u808c\u9178\u9150\u6bd4\u7387 UACR \u2267 200 mg\/g<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u6709\u591a\u56ca\u6027\u814e\u75c5\uff08polycystic kidney disease\uff09\u548c\u5df2\u7d93\u63a5\u53d7\u814e\u81df\u79fb\u690d\uff08received kidney transplant\uff09\u8005\u88ab<span style=\"text-decoration: underline;\">\u6392\u9664\u6536\u6848<\/span>\u3002<\/p>\n\n\n\n<p>\u6536\u6848\u65cf\u7fa4\u9996\u5148\u6703\u7d93\u904e 8-12 \u9031 run-in phase\uff0c\u78ba\u4fdd\u6709\u670d\u7528\u81e8\u5e8a\u4e0a\u9069\u7576\u5291\u91cf\u7684 RAS blocker\uff0c\u4ee5\u53ca\u4e0d\u8981 RAS blocker \u548c SGLT2i \u4e00\u8d77\u52a0\u4e0a\u9020\u6210\u526f\u4f5c\u7528\uff0c\u4e0d\u904e\u7121\u6cd5\u8010\u53d7 RAS blocker \u7684\u4eba\u9084\u662f\u53ef\u4ee5\u6536\u6848\uff0c\u6700\u7d42\u6536\u6848\u65cf\u7fa4\u6709 85% \u662f\u6709\u4f7f\u7528 RAS blocker \u3002<\/p>\n\n\n\n<p>\u53e6\u5916\uff0c\u672c\u7814\u7a76\u6c92\u6709\u9650\u5236\u7cd6\u5c3f\u75c5\uff0c\u56e0\u6b64\u6536\u6848\u65cf\u7fa4\u300c\u6c92\u6709\u300d\u7cd6\u5c3f\u75c5\u8005\u4f54 54%\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u6700\u7d42\u7e3d\u5171\u6536\u6848 6,609 \u4eba\uff0c1\uff1a1 \u96a8\u6a5f\u5206\u6d3e\u4f7f\u7528 empagliflozin 10mg QD \u6216 placebo\u3002<\/p>\n\n\n\n<p>\u7d50\u679c\u986f\u793a<strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">\u9996\u6b21\u767c\u751f\u814e\u81df\u60e1\u5316\u6216\u5fc3\u56e0\u6027\u6b7b\u4ea1\u98a8\u96aa\uff0c\u986f\u8457\u4e0b\u964d 28%\uff08HR 0.72, 95% CI 0.64-0.82\uff09<\/mark><\/strong>\uff0c\u6bcf\u5e74\u6bcf 1000 \u4eba\u53ef\u6e1b\u5c11 21 \u500b\u4e8b\u4ef6\u767c\u751f\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u751a\u81f3\u56e0\u70ba\u592a\u6709\u6548\uff0c\u9032\u884c\u671f\u4e2d\u5206\u6790\u6642\u767c\u73fe\u4f7f\u7528 empagliflozin \u76f8\u8f03\u65bc\u5c0d\u7167\u7d44\uff0c\u5c0d\u65bc\u814e\u81df\u98a8\u96aa\u6709\u660e\u986f\u4e0b\u964d\uff0c\u70ba\u4e86\u502b\u7406\u8003\u91cf\uff08\u7e7c\u7e8c\u6536\u6848\u5c0d placebo \u7d44\u4e0d\u516c\u5e73\uff09\uff0c2022\/3\/7 \u5c31\u63d0\u65e9\u505c\u6b62\u6536\u6848\uff08stopping early\uff09\u3002<\/p>\n\n\n\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"575\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-3-1024x575.jpg\" alt=\"\" class=\"wp-image-4539\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-3-1024x575.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-3-300x168.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-3-768x431.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-3-1170x657.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-3-585x328.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-3.jpg 1283w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Empagliflozin \u7528\u65bc CKD \u65cf\u7fa4\uff0c\u7d04 1.5 \u5e74\u51fa\u73fe\u9ec3\u91d1\u4ea4\u53c9<\/figcaption><\/figure>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u53e6\u5916\u6211\u6eff\u597d\u5947\u7684\u662f\uff0c\u5927\u5bb6\u90fd\u8aaa SGLT2i \u548c RAS blocker \u4e00\u6a23\uff0c\u5c0d\u814e\u81df\u6709\u4fdd\u8b77\u6548\u679c\uff0c\u4f46\u521d\u671f\u4f7f\u7528\u537b\u53c8\u6703\u4e0b\u964d eGFR\u3002<\/p>\n\n\n\n<p>\u672c\u7814\u7a76\u7684\u78ba\u986f\u793a\uff0c<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"><strong>empagliflozin \u525b\u52a0\u4e0a\u53bb\u7684\u524d\u5169\u500b\u6708\uff0ceGFR \u6703\u5148\u4e0b\u964d\u7d04 2-3 \u500b\u55ae\u4f4d\uff0c\u4e0d\u904e 18 \u500b\u6708\uff08\u7d04 1.5 \u5e74\uff09\u5f8c\u6703\u51fa\u73fe\u9ec3\u91d1\u4ea4\u53c9<\/strong><\/mark>\uff0c\u6240\u4ee5\u9084\u662f\u8981\u4e56\u4e56\u9577\u671f\u7684\u5403\u85e5\u624d\u80fd\u5ef6\u7de9 eGFR \u4e0b\u964d\u3002<\/p>\n\n\n\n<p>\u6b21\u65cf\u7fa4\u5206\u6790\u770b\u5230\uff0c\u5c0d\u65bc<strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\">\u6709\u7cd6\u5c3f\u75c5\u3001eGFR \u2267 45 \u6216 UACR\uff1e300 \u7684\u65cf\u7fa4<\/mark><\/strong>\uff0cempagliflozin \u5c0d\u65bc\u5fc3\u814e\u4fdd\u8b77\u7684\u6548\u679c\u66f4\u986f\u8457\u5594\uff01<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Empagliflozin_%E5%AE%89%E5%85%A8%E6%80%A7\"><\/span><strong>Empagliflozin \u5b89\u5168\u6027<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u8b1b\u5230 SGLT2i \u7684\u526f\u4f5c\u7528\uff0c\u6700\u64d4\u5fc3\u7684\u5c31\u662f\u916e\u9178\u4e2d\u6bd2\u548c\u6ccc\u5c3f\u9053\u611f\u67d3\u3002<\/p>\n\n\n\n<p>\u4e0d\u904e\u672c\u7814\u7a76\u986f\u793a\uff0c<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"><strong>empagliflozin 10mg \u76f8\u8f03\u65bc placebo\uff0c\u56b4\u91cd\u526f\u4f5c\u7528\u6c92\u6709\u986f\u8457\u5dee\u7570\uff01<\/strong><\/mark><\/p>\n\n\n\n<p>Empagliflozin \u7d44\u6709 6 \u540d\u60a3\u8005\u767c\u751f\u916e\u75c7\u9178\u4e2d\u6bd2\uff0c\u5b89\u6170\u5291\u7d44\u6709 1 \u540d\u60a3\u8005\u767c\u751f\u916e\u9178\u4e2d\u6bd2\uff08\u5206\u5225\u70ba\u6bcf 100 \u4eba\/\u5e74\uff0c0.09 \u4f8b vs. 0.02 \u4f8b\uff09\u3002<\/p>\n\n\n\n<p>Empagliflozin \u7d44\u6709 28 \u540d\u60a3\u8005\u767c\u751f\u4e0b\u80a2\u622a\u80a2\uff0c\u5b89\u6170\u5291\u7d44\u6709 19 \u540d\u60a3\u8005\u767c\u751f\u4e0b\u80a2\u622a\u80a2\uff08\u5206\u5225\u70ba\u6bcf 100 \u4eba\/\u5e74\uff0c0.43 \u4f8b vs. 0.29 \u4f8b\uff09\u3002<\/p>\n\n\n\n<p>\u5169\u7d44\u56b4\u91cd\u6ccc\u5c3f\u9053\u611f\u67d3\u3001\u9ad8\u8840\u9240\u3001\u6025\u6027\u814e\u640d\u50b7\u3001\u56b4\u91cd\u6216\u6709\u75c7\u72c0\u812b\u6c34\u3001\u809d\u640d\u50b7\u548c\u9aa8\u6298\u7684\u767c\u751f\u7387\u5927\u81f4\u76f8\u4f3c\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"575\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-6-1024x575.jpg\" alt=\"\" class=\"wp-image-4549\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-6-1024x575.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-6-300x168.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-6-768x431.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-6-1170x657.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-6-585x328.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-6.jpg 1283w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Empagliflozin \u526f\u4f5c\u7528\u6c92\u6709\u986f\u8457\u589e\u52a0<\/figcaption><\/figure>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"818\" height=\"560\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-8.jpg\" alt=\"\" class=\"wp-image-4556\" style=\"aspect-ratio:1.4607142857142856;width:559px;height:auto\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-8.jpg 818w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-8-300x205.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-8-768x526.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-8-585x400.jpg 585w\" sizes=\"(max-width: 818px) 100vw, 818px\" \/><figcaption class=\"wp-element-caption\">Empagliflozin \u7d44\u767c\u751f\u916e\u9178\u4e2d\u6bd2\u8207\u4e0b\u80a2\u622a\u80a2\u7684\u4eba\u6578\u770b\u8d77\u4f86\u6bd4\u8f03\u591a<\/figcaption><\/figure><\/div>\n\n\n<p>\u4e0d\u904e\u55ae\u770b\u4eba\u6578\uff0cEmpagliflozin \u7d44\u767c\u751f\u916e\u9178\u4e2d\u6bd2\uff08Ketoacidosis\uff09\u8207\u4e0b\u80a2\u622a\u80a2\uff08Lower-limb amputations\uff09\u7684\u4eba\u6578\u6bd4\u8f03\u591a\uff0c\u96d6\u7136\u6c92\u6709\u986f\u8457\u5dee\u7570\uff0c\u9084\u662f\u8981\u7279\u5225\u7559\u610f\u9019\u65b9\u9762\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Empagliflozin_%E5%A6%82%E4%BD%95%E6%94%B9%E5%96%84%E8%85%8E%E5%8A%9F%E8%83%BD%EF%BC%9F\"><\/span><strong>Empagliflozin \u5982\u4f55\u6539\u5584\u814e\u529f\u80fd\uff1f<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-5-1024x576.jpg\" alt=\"\" class=\"wp-image-4545\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-5-1024x576.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-5-300x169.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-5-768x432.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-5-1170x659.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-5-585x329.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-5.jpg 1279w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Empagliflozin \u6539\u5584\u814e\u529f\u80fd\u7684\u53ef\u80fd\u6a5f\u8f49<\/figcaption><\/figure>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u814e\u81df\u5177\u6709\u814e\u5c0f\u7ba1\u814e\u7d72\u7403\u56de\u994b\u6a5f\u5236\uff08tubuloglomerular feedback, TGF\uff09\u3002<\/p>\n\n\n\n<p>\uff08\u4e0a\u5716\u5de6\u5074\uff09<\/p>\n\n\n\n<p>\u814e\u81df\u900f\u904e\u8fd1\u814e\u7d72\u7403\u5668\uff08juxtaglomerular apparatus, JGA\uff09\u4e2d\u7684\u7dfb\u5bc6\u6591\uff08macula densa\uff09\uff0c\u611f\u53d7\u9060\u7aef\u5c0f\u7ba1\u4e2d\u9209\u96e2\u5b50\u6fc3\u5ea6\u9ad8\u4f4e\uff0c\u4ee5\u8abf\u63a7\u5165\u7403\u53ca\u51fa\u7403\u5c0f\u52d5\u8108\u7ba1\u5f91\uff0c\u56e0\u7ba1\u5f91\u8212\u5f35\u6536\u7e2e\u6240\u5f62\u6210\u7684\u814e\u7d72\u7403\u904e\u6ffe\u58d3\uff0c\u4f86\u7a69\u5b9a\u814e\u7d72\u7403\u904e\u6ffe\u7387\uff08glomerular filtration rate, GFR)\u3002<\/p>\n\n\n\n<p>\u7576\u814e\u7d72\u7403\u904e\u6ffe\u7387\u589e\u52a0\uff0c\u5165\u7403\u5c0f\u52d5\u8108\u8840\u6d41\u589e\u52a0\uff0c\u7dfb\u5bc6\u6591\u611f\u53d7\u9209\u96e2\u5b50\u589e\u52a0\uff0c\u85c9\u7531 TGF \u8abf\u63a7\u5165\u7403\u5c0f\u52d5\u8108\u6536\u7e2e\uff0c\u6e1b\u5c11\u6d41\u5165\u814e\u7d72\u7403\u7684\u8840\u6db2\uff0c\u4ee5\u9054\u5230\u964d\u4f4e\u814e\u7d72\u7403\u904e\u6ffe\u58d3\uff0c\u9032\u800c\u964d\u4f4e\u814e\u7d72\u7403\u904e\u6ffe\u7387\u4f86\u800c\u9054\u5230\u5e73\u8861\u3002<\/p>\n\n\n\n<p>\uff08\u4e0a\u5716\u4e2d\u9593\uff09<\/p>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u60a3\u8005\u56e0\u8fd1\u7aef\u5c0f\u7ba1 SGLT-2 \u5927\u91cf\u56de\u6536\u8461\u8404\u7cd6\u8207\u9209\uff0c\u7dfb\u5bc6\u6591\u611f\u53d7\u4e0d\u5230\u9209\u96e2\u5b50\uff0c\u56e0\u6b64\u6291\u5236 TGF \u8abf\u63a7\u6a5f\u5236\uff0c\u589e\u52a0\u814e\u7d20\u5206\u6ccc\uff0c\u6536\u7e2e\u51fa\u7403\u5c0f\u52d5\u8108\uff0c\u63d0\u9ad8\u814e\u7d72\u7403\u904e\u6ffe\u58d3\uff0c\u9020\u6210\u814e\u7d72\u7403\u904e\u5ea6\u904e\u6ffe\uff0c\u9577\u671f\u9ad8\u58d3\u4e0b\uff0c\u6703\u9020\u6210\u814e\u81df\u6ffe\u819c\u640d\u50b7\uff0c\u9032\u800c\u7522\u751f\u86cb\u767d\u5c3f\u53ca\u814e\u529f\u80fd\u60e1\u5316\u3002<\/p>\n\n\n\n<p>\uff08\u4e0a\u5716\u53f3\u5074\uff09<\/p>\n\n\n\n<p>SGLT-2 \u6291\u5236\u5291\u963b\u65b7\u8461\u8404\u7cd6\u8207\u9209\u518d\u5438\u6536\uff0c\u589e\u52a0\u7dfb\u5bc6\u73ed\u611f\u53d7\u9209\u96e2\u5b50\uff0cTGF \u6062\u5fa9\u8abf\u63a7\uff0c\u6536\u7e2e\u5165\u7403\u5c0f\u52d5\u8108\u6e1b\u5c11\u8840\u6d41\u91cf\uff0c\u964d\u4f4e\u814e\u7d72\u7403\u904e\u6ffe\u58d3\u53ca\u904e\u6ffe\u7387\u3002<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/tina016-sglt2-inhibitor-renal\/\">\u3010\u8b80\u66f8\u7b46\u8a18\u3011SGLT2\u6291\u5236\u5291\u9069\u61c9\u75c7\u8207\u814e\u529f\u80fd\u4e0d\u5168\u9650\u5236<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Empagliflozin_10mg_%E4%BB%BF%E5%96%AE%E4%BF%AE%E8%A8%82%EF%BC%9A%E6%94%BE%E5%AF%AC%E8%85%8E%E5%8A%9F%E8%83%BD%E4%BD%BF%E7%94%A8%E9%99%90%E5%88%B6\"><\/span><strong>Empagliflozin 10mg \u4eff\u55ae\u4fee\u8a02\uff1a\u653e\u5bec\u814e\u529f\u80fd\u4f7f\u7528\u9650\u5236<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"575\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-7-1024x575.jpg\" alt=\"\" class=\"wp-image-4550\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-7-1024x575.jpg 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-7-300x168.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-7-768x431.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-7-1170x657.jpg 1170w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-7-585x328.jpg 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/10\/EMPA-KIDNEY-7.jpg 1283w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Empagliflozin 10mg \u4eff\u55ae\u5167\u5bb9\u4fee\u8a02<\/figcaption><\/figure>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>112\/8\/24 Empagliflozin 10mg \u4eff\u55ae\u4e2d\u95dc\u65bc\u814e\u529f\u80fd\u4e0d\u5168\u7684\u4f7f\u7528\u9650\u5236\u653e\u5bec\u4e86\uff08\u7051\u82b1\uff5e\uff09\u3002<\/p>\n\n\n\n<p>\u539f\u672c eGFR\uff1c20-30 \u5c31\u4e0d\u5efa\u8b70\u4f7f\u7528\uff0c\u5f8c\u4f86\u653e\u5bec\u70ba\u300c<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"><strong>\u50c5\u900f\u6790\u75c5\u4eba\u4e0d\u5efa\u8b70\u4f7f\u7528<\/strong><\/mark>\u300d\uff0c\u771f\u662f\u53ef\u559c\u53ef\u8cc0\uff5e<\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">\u4e0d\u904e SGLT2i \u7684\u9069\u61c9\u75c7\u548c\u5065\u4fdd\u7d66\u4ed8\u898f\u7bc4\u9084\u662f\u6709\u843d\u5dee\uff0c\u6574\u7406\u5982\u4e0b\u8868\uff1a<\/mark><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table is-style-stripes\"><table class=\"has-fixed-layout\"><thead><tr><th>\u75be\u75c5<\/th><th>\u7cd6\u5c3f\u75c5<\/th><th>\u6162\u6027\u814e\u81df\u75c5<\/th><th>\u5fc3\u81df\u8870\u7aed<\/th><\/tr><\/thead><tbody><tr><td><strong>\u4eff\u55ae\u6838\u51c6\u9069\u61c9\u75c7<\/strong><\/td><td>\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5<br>eGFR \u2267 30 mL\/min\/1.73^2<\/td><td>\u6162\u6027\u814e\u81df\u75c5<\/td><td>\u5fc3\u81df\u8870\u7aed<br>NYHA II\uff5eIV<\/td><\/tr><tr><td><strong>\u5065\u4fdd\u7d66\u4ed8\u898f\u7bc4<\/strong><\/td><td>\u5df2\u63a5\u53d7\u904e\u6700\u5927\u8010\u53d7\u5291\u91cf  metformin \u4ecd\u7121\u6cd5\u7406\u60f3\u63a7\u5236\u8840\u7cd6\uff0c\u6216\u6709 metformin \u904e\u654f\/\u7981\u5fcc\u75c7<br>SGLT2i\u3001DPP4i\u3001SGLT2i\/DPP4i \u8907\u65b9\uff0c\u64c7\u4e00\u4f7f\u7528<\/td><td>\u7121<\/td><td>LVEF \u2266 40%<br>\u7d93 ACEI\/ARB + beta-blocker \u7a69\u5b9a\u6cbb\u7642 4 \u9031<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">SGLT2i \u7684\u9069\u61c9\u75c7\u548c\u5065\u4fdd\u7d66\u4ed8\u898f\u7bc4\u6bd4\u8f03<\/figcaption><\/figure>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group list\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\u6839\u64da\u4e0a\u8868\uff0c\u6216\u8a31\u4ee5\u4e0b\u65cf\u7fa4\u9700\u8981\u81ea\u8cbb\u4f7f\u7528 SGLT2i \u85e5\u7269\u5594\uff01<\/p>\n\n\n\n<ul>\n<li>\u50c5\u6162\u6027\u814e\u81df\u75c5\uff0c\u4f46\u6c92\u6709\u5408\u4f75\u7cd6\u5c3f\u75c5\u6216\u5fc3\u81df\u8870\u7aed<\/li>\n\n\n\n<li>\u5fc3\u81df\u8870\u7aed\uff0cLVEF \uff1e40%<\/li>\n\n\n\n<li>\u5fc3\u81df\u8870\u7aed\uff0cLVEF \u2266 40%\uff0c\u4f46\u5c1a\u672a\u7d93 ACEI\/ARB + beta-blocker \u7a69\u5b9a\u6cbb\u7642 4 \u9031\uff0c\u5c31\u60f3\u540c\u6642\u52a0\u4e0a SGLT2i<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<p>\u7b2c\u4e09\u9ede\u771f\u7684\u662f\u6211\u5011\u91ab\u9662\u5fc3\u81df\u79d1\u91ab\u5e2b\u7684\u7b56\u7565\uff0c\u56e0\u70ba\u7814\u7a76\u986f\u793a\uff0c\u7b2c\u4e00\u500b\u6708\u7528\u4e0a SGLT2i \u5c31\u53ef\u4ee5\u770b\u5230\u597d\u8655\uff0c\u6240\u4ee5\u91ab\u5e2b\u6703\u5efa\u8b70\u75c5\u4eba\u5148\u81ea\u8cbb\u4e00\u500b\u6708\uff0c\u4e4b\u5f8c\u518d\u6539\u7528\u5065\u4fdd\u65b9\u5f0f\u958b\u7acb SGLT2i\u3002<\/p>\n\n\n\n<p>\u7562\u7adf Empagliflozin 10mg \u7684<a href=\"https:\/\/www.nhi.gov.tw\/QueryN_New\/QueryN\/Query1\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/www.nhi.gov.tw\/QueryN_New\/QueryN\/Query1\" rel=\"noreferrer noopener\"><span style=\"text-decoration: underline;\">\u5065\u4fdd\u50f9<\/span><\/a>\u4e00\u9846\u662f 28.8 \u5143\uff0c 30 \u5929\u7684\u85e5\u8cbb\u4e5f\u624d 864 \u5143\uff0c\u5212\u7b97\u7684\u5f88~<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B5%90%E8%AA%9E\"><\/span><strong>\u7d50\u8a9e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>SGLT2i \u771f\u7684\u662f\u5f88\u53b2\u5bb3\uff0c\u611f\u89ba\u662f\u65b0\u4e00\u4ee3\u795e\u85e5\uff0c\u6bcf\u5e74\u7684\u6cbb\u7642\u6307\u5f15\u4e5f\u56e0\u70ba SGLT2i \u6301\u7e8c\u66f4\u65b0\uff01<\/p>\n\n\n\n<p>\u9664\u4e86\u7cd6\u5c3f\u75c5\uff0c\u814e\u81df\u75c5\u3001\u5fc3\u81df\u8870\u7aed\u90fd\u53ef\u4ee5\u4e0b\u964d\u75be\u75c5\u98a8\u96aa\uff0c\u4e14\u4e0d\u7ba1\u6709\u7121\u7cd6\u5c3f\u75c5\u3001LVEF \u6578\u503c\u9ad8\u4f4e\u90fd\u53ef\u4ee5\u770b\u5230\u4e00\u81f4\u7684\u597d\u8655\u3002<\/p>\n\n\n\n<p>\u53c8\u53ef\u4ee5\u964d\u9ad4\u91cd\u3001\u964d\u8840\u58d3\uff0c\u6211\u9694\u58c1\u540c\u4e8b\u9084\u554f\u6211\uff0c\u9084\u662f\u54b1\u73fe\u5728\u5c31\u53ef\u4ee5\u53bb\u8cb7\u85e5\u4f86\u5403\u4e86\uff08\u8aa4 XD\uff09\u3002<\/p>\n\n\n\n<p>\u63a5\u4e0b\u4f86\u5c31\u7b49\u5176\u4ed6 SGLT2i \u662f\u5426\u6709\u76f8\u95dc\u7814\u7a76\u767c\u8868\uff0c\u4e0d\u7136\u5404\u7a2e SGLT2i \u5728\u9069\u61c9\u75c7\u90fd\u6709\u4e9b\u8a31\u4e0d\u540c\uff0c\u5be6\u5728\u662f\u5f88\u96e3\u8a18\u61b6\u963f QQ<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/g002\/\">\u3010\u6cbb\u7642\u6307\u5f15\u3011\u5fc3\u81df\u8870\u7aed\u6cbb\u7642\u6307\u5f15\u5927\u66f4\u65b0\uff012021 ESC \u6b50\u6d32\u5fc3\u81df\u5b78\u6703<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group box\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\u4f60\u662f\u91ab\u9662\u85e5\u5e2b\u6216\u8b77\u7406\u5e2b\u55ce\uff1f<\/p>\n\n\n\n<p>\u6642\u5e38\u9047\u5230\u75c5\u4eba\u8981\u7d66\u8a31\u591a\u91dd\u5291\u85e5\u54c1\uff0c\u7919\u65bc\u7ba1\u8def\u4e0d\u5920\u9700\u8981\u540c\u6642\u7d66\u85e5 &#8230;&#8230;<\/p>\n\n\n\n<p>\u537b\u4e0d\u77e5\u9053\u9019\u4e9b\u85e5\u7269\u53ef\u4e0d\u53ef\u4ee5\u65c1\u63d2\u4f7f\u7528\u55ce\uff1f<\/p>\n\n\n\n<p>\u5225\u64d4\u5fc3\uff01<\/p>\n\n\n\n<p>\u5c0f\u6db5\u85e5\u5e2b\u6574\u7406\u4e86\u4f4f\u9662\u75c5\u4eba\u5e38\u7528\u7684\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\uff0c\u6b61\u8fce\u9ede\u64ca\u4e0b\u5716\u7d22\u53d6\u5594\uff01<\/p>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/subscribepage.io\/EPTKCz\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-1024x574.png\" alt=\"\" class=\"wp-image-3721\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-1024x574.png 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-300x168.png 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-768x431.png 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-585x328.png 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716.png 1038w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/subscribepage.io\/o1gTEc\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" width=\"1024\" height=\"573\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-1024x573.png\" alt=\"\" class=\"wp-image-3722\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-1024x573.png 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-300x168.png 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-768x430.png 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716-585x327.png 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91ab\u85e5\u7b46\u8a18\u6587\u7ae0\u5927\u5716.png 1038w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>2023\/1\/12 EMPA-KIDNEY \u7814\u7a76\u767c\u8868\uff0c\u8a55\u4f30 Empagliflozin 10mg QD \u5c0d\u814e\u81df\u75be\u75c5\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u9032\u5c55\u7684\u5f71\u97ff\uff0c\u4ee5\u53ca\u672c\u85e5\u5728 CKD \u65cf\u7fa4\u4e2d\u7684\u5b89\u5168\u6027\uff0c\u7d50\u679c\u986f\u793a\u53ef\u4ee5\u986f\u8457\u4e0b\u964d\u9996\u6b21\u767c\u751f\u814e\u81df\u60e1\u5316\u6216\u5fc3\u56e0\u6027\u6b7b\u4ea1\u98a8\u96aa\u3002\u672c\u6587\u9084\u6574\u7406\u4e86 SGLT2i \u4fdd\u8b77\u814e\u81df\u7684\u6a5f\u8f49\uff0c\u4ee5\u53ca empagliflozin \u4eff\u55ae\u4fee\u8a02\u5167\u5bb9\uff0c\u5feb\u4f86\u770b\u770b\u5427\uff01<\/p>\n","protected":false},"author":1,"featured_media":4559,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[106],"tags":[123,84,124,74],"table_tags":[],"modified_by":"\u5c0f\u6db5\u85e5\u5e2b","_links":{"self":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/4536"}],"collection":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/comments?post=4536"}],"version-history":[{"count":2,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/4536\/revisions"}],"predecessor-version":[{"id":4561,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/4536\/revisions\/4561"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/media\/4559"}],"wp:attachment":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/media?parent=4536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/categories?post=4536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/tags?post=4536"},{"taxonomy":"table_tags","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/table_tags?post=4536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}