{"id":2262,"date":"2022-01-18T01:04:54","date_gmt":"2022-01-17T17:04:54","guid":{"rendered":"https:\/\/tinapoint.com\/?p=2262"},"modified":"2023-10-28T20:26:17","modified_gmt":"2023-10-28T12:26:17","slug":"tina016-sglt2-inhibitor-renal","status":"publish","type":"post","link":"https:\/\/tinapoint.com\/tina016-sglt2-inhibitor-renal\/","title":{"rendered":"\u3010\u8b80\u66f8\u7b46\u8a18\u3011SGLT2\u6291\u5236\u5291\u9069\u61c9\u75c7\u8207\u814e\u529f\u80fd\u4e0d\u5168\u9650\u5236"},"content":{"rendered":"\n<p>\u5e02\u9762\u4e0a\u6709\u8d8a\u4f86\u8d8a\u591a\u7a2e\u7684 SGLT2 \u6291\u5236\u5291\u85e5\u54c1\uff0c\u55ae\u65b9\u52a0\u8907\u65b9\u7433\u746f\u6eff\u76ee\uff0c\u5916\u52a0\u5404\u81ea\u4e0d\u540c\u7684\u814e\u529f\u80fd\u9650\u5236\uff0c\u4f60\u80fd\u8a8d\u6e05\u55ce\uff1f\u672c\u6587\u8a73\u7d30\u6574\u7406\u4e86\u570b\u5167\u4eff\u55ae\u8207\u7f8e\u570b Uptodate \u8cc7\u6599\u5eab\u5c0d SGLT2 \u6291\u5236\u5291\u85e5\u54c1\u7684\u9069\u61c9\u75c7\u8207\u814e\u529f\u80fd\u898f\u7bc4\uff0c\u6b61\u8fce\u5927\u5bb6\u53d6\u7528\uff5e<\/p>\n\n\n\n<!--more-->\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_50 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\">\u5167\u5bb9\u76ee\u9304<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\" role=\"button\"><label for=\"item-663b03c2c3638\" aria-hidden=\"true\"><span style=\"display: flex;align-items: center;width: 35px;height: 30px;justify-content: center;direction:ltr;\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/label><input  type=\"checkbox\" id=\"item-663b03c2c3638\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/tinapoint.com\/tina016-sglt2-inhibitor-renal\/#%E5%89%8D%E8%A8%80\" title=\"\u524d\u8a00\">\u524d\u8a00<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/tinapoint.com\/tina016-sglt2-inhibitor-renal\/#SGLT2_%E6%8A%91%E5%88%B6%E5%8A%91%E8%85%8E%E5%8A%9F%E8%83%BD%E5%8A%91%E9%87%8F%E8%AA%BF%E6%95%B4\" title=\"SGLT2 \u6291\u5236\u5291\u814e\u529f\u80fd\u5291\u91cf\u8abf\u6574\">SGLT2 \u6291\u5236\u5291\u814e\u529f\u80fd\u5291\u91cf\u8abf\u6574<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/tinapoint.com\/tina016-sglt2-inhibitor-renal\/#%E6%9C%AC%E9%99%A2_SGLT2_%E6%8A%91%E5%88%B6%E5%8A%91%E7%A8%AE%E9%A1%9E\" title=\"\u672c\u9662 SGLT2 \u6291\u5236\u5291\u7a2e\u985e\">\u672c\u9662 SGLT2 \u6291\u5236\u5291\u7a2e\u985e<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/tinapoint.com\/tina016-sglt2-inhibitor-renal\/#%E5%BE%8C%E8%A9%B1\" title=\"\u5f8c\u8a71\">\u5f8c\u8a71<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/tinapoint.com\/tina016-sglt2-inhibitor-renal\/#%E7%9B%B8%E9%97%9C%E6%96%87%E7%AB%A0\" title=\"\u76f8\u95dc\u6587\u7ae0\">\u76f8\u95dc\u6587\u7ae0<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\" id=\"\u524d\u8a00\"><span class=\"ez-toc-section\" id=\"%E5%89%8D%E8%A8%80\"><\/span><strong>\u524d\u8a00<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>\u9209-\u8461\u8404\u7cd6\u5171\u540c\u8f49\u904b\u5668\u20132\u6291\u5236\u5291\uff08SGLT2 inhibition\uff0c\u5f8c\u9762\u7c21\u7a31 SGLT2 \u6291\u5236\u5291\uff09<\/strong>\u662f\u76ee\u524d\u7cd6\u5c3f\u75c5\u6cbb\u7642\u7528\u85e5\u4e2d\uff0c\u552f\u4e00\u53ef\u4ee5\u771f\u6b63\u4fc3\u9032\u8840\u7cd6\u5f9e\u5c3f\u6db2\u4e2d\u6392\u9664\u7684\u85e5\u7269\u3002<\/p>\n\n\n\n<p>\u4e3b\u8981\u6a5f\u8f49\u4f5c\u7528\u5728\u814e\u81df\u814e\u5c0f\u7ba1\u8fd1\u7aef SGLT2 \u53d7\u9ad4\uff0c\u628a\u5927\u90e8\u5206\u5c3f\u7cd6\u6392\u51fa\u9ad4\u5916\u800c\u964d\u4f4e\u8840\u7cd6\uff0c\u6bcf\u5929\u7d04\u53ef\u6392\u51fa\u7d04 78 \u516c\u514b\u8461\u8404\u7cd6\uff0c\u53e6\u5916\u540c\u6642\u6392\u51fa\u9209\u96e2\u5b50\u800c\u6709\u5229\u5c3f\u964d\u8840\u58d3\u4f5c\u7528\uff0c\u6bcf\u5929\u7d04\u589e\u52a0 500 mL \u5c3f\u6db2\u6392\u9664\u3002<\/p>\n\n\n\n<p class=\"box\">P.S. \u5176\u9918\u964d\u8840\u7cd6\u85e5\u7269\u7684\u6a5f\u8f49\u5305\u62ec\u6e1b\u5c11\u7cd6\u5206\u5438\u6536\u3001\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u548c\u589e\u52a0\u80f0\u5cf6\u7d20\u654f\u611f\u6027\uff0c\u4f7f\u8840\u7cd6\u9032\u5165\u5668\u5b98\u4e2d\u61c9\u7528\uff0c\u4f46\u9019\u4e9b\u7cd6\u5206\u9084\u662f\u5728\u4f60\u7684\u8eab\u9ad4\u4e2d\uff0c\u53ea\u662f\u964d\u4f4e\u8840\u6db2\u4e2d\u7684\u7cd6\u5206\uff0c\u8b93\u4f60\u7684\u8840\u7ba1\u4e0d\u6703\u6ce1\u5728\u7cd6\u6c34\u4e2d\u3002<\/p>\n\n\n\n<p>\u7531\u65bc\u904e\u53bb TZD \u985e\u964d\u8840\u7cd6\u85e5\u54c1\u68b5\u5e1d\u96c5\uff08Avandia\uff0cRosiglitazone\uff09\u5728 2007 \u5e74 Nissen \u7684\u7d71\u5408\u5206\u6790\uff08meta-analysis\uff09\u767c\u73fe\u53ef\u80fd\u589e\u52a043% \u5fc3\u808c\u6897\u585e\u98a8\u96aa\uff0c\u56e0\u6b64\u800c\u4e0b\u5e02\u3002\u81ea\u6b64\u4e4b\u5f8c\uff0c<strong>\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 FDA \u65bc 2008 \u5e74\u8d77\uff0c\u5efa\u8b70\u6240\u6709\u65b0\u4e0a\u5e02\u7684\u964d\u8840\u7cd6\u85e5\uff0c\u9700\u5728\u6709\u9ad8\u98a8\u96aa\u7684\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\uff0c\u9032\u884c\u5fc3\u8840\u7ba1\u7d50\u679c\u8a66\u9a57\uff08cardiovascular outcome trial, CVOT\uff09\uff0c\u8b49\u660e\u5b89\u5168\u6027<\/strong>\u3002<\/p>\n\n\n\n<p>\u7d50\u679c SGLT2 \u6291\u5236\u5291\u4e0d\u4f46\u6c92\u6709\u5fc3\u8840\u7ba1\u7591\u616e\uff0c\u751a\u81f3\u9084\u6709\u5fc3\u8840\u7ba1\u4fdd\u8b77\u6548\u679c\uff0c\u5c0d\u6162\u6027\u814e\u81df\u75be\u75c5\u4e5f\u6709\u597d\u8655\uff0c\u6574\u500b\u5c31\u662f\u64bf\u5230\u69cd\u554a\uff01\u5f8c\u7e8c\u7814\u7a76\u767c\u73fe\u6c92\u6709\u7cd6\u5c3f\u75c5\u8005\uff0c\u4e5f\u80fd\u7372\u5f97\u597d\u8655\uff0c\u8868\u793a\u5fc3\u8840\u7ba1\u597d\u8655\u53ef\u80fd\u4e0d\u662f\u4f86\u81ea\u65bc\u6392\u7cd6\uff0c\u800c\u662f\u5176\u4ed6\u6a5f\u8f49\uff0c\u8b93 SGLT2 \u6291\u5236\u5291\u7684\u7814\u7a76\u5982\u96e8\u5f8c\u6625\u7b4d\u822c\u5192\u51fa\uff01<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u6709\u95dc SGLT2 \u6291\u5236\u5291\u5c0d\u65bc\u5fc3\u81df\u8870\u7aed\u7684\u597d\u8655\uff0c\u5148\u524d\u6211\u6709\u5beb\u904e\u5169\u7bc7\u6587\u7ae0\u3002<\/p>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/r001\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u3010\u6587\u737b\u5c0e\u8b80\u3011EMPAGLIFLOZIN\u964d\u4f4e\u5fc3\u8870\u7aed\u75c5\u4eba25%\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\uff0c\u4e0d\u7ba1\u6709\u7121\u7cd6\u5c3f\u75c5(EMPEROR-REDUCED)<\/a> <\/strong><\/p>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a <a href=\"https:\/\/tinapoint.com\/r003\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u3010\u6587\u737b\u5c0e\u8b80\u3011\u5fc3\u8870\u7aed\u91cd\u5927\u7a81\u7834\uff01Empagliflozin\u53ef\u4ee5\u964d\u4f4eLVEF\uff1e40%\u65cf\u7fa4\u7684\u98a8\u96aa(EMPEROR-Preserved)<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"sglt2-\u6291\u5236\u5291\u814e\u529f\u80fd\u5291\u91cf\u8abf\u6574\"><span class=\"ez-toc-section\" id=\"SGLT2_%E6%8A%91%E5%88%B6%E5%8A%91%E8%85%8E%E5%8A%9F%E8%83%BD%E5%8A%91%E9%87%8F%E8%AA%BF%E6%95%B4\"><\/span><strong>SGLT2 \u6291\u5236\u5291\u814e\u529f\u80fd\u5291\u91cf\u8abf\u6574<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u73fe\u5728\u5e02\u9762\u4e0a\u6709\u8a31\u591a SGLT2 \u6291\u5236\u5291\u4e0a\u5e02\uff0c\u9084\u6709\u773e\u591a\u8907\u65b9\uff0c\u6bcf\u7a2e\u5c0d\u65bc\u814e\u529f\u80fd\u7684\u9650\u5236\u90fd\u4e0d\u592a\u4e00\u6a23\u3002<\/p>\n\n\n\n<p>\u4e00\u6709\u65b0\u7684\u7814\u7a76\u53c8\u6703\u66f4\u65b0\uff0c\u5be6\u5728\u592a\u96e3\u8a18\u4e86&#8230;&#8230; <\/p>\n\n\n\n<p>\u6240\u4ee5\u6211\u5c31\u505a\u51fa\u4e86\u9019\u5f35\u6574\u7406\u8868\u5566\uff01<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img decoding=\"async\" width=\"960\" height=\"720\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2022\/01\/016-SGLT2\u6291\u5236\u5291\u814e\u529f\u80fd\u8abf\u6574\u7e3d\u6574\u7406.jpg\" alt=\"SGLT2\u6291\u5236\u5291\u814e\u529f\u80fd\u8abf\u6574\u7e3d\u6574\u7406\" class=\"wp-image-2269\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2022\/01\/016-SGLT2\u6291\u5236\u5291\u814e\u529f\u80fd\u8abf\u6574\u7e3d\u6574\u7406.jpg 960w, https:\/\/tinapoint.com\/wp-content\/uploads\/2022\/01\/016-SGLT2\u6291\u5236\u5291\u814e\u529f\u80fd\u8abf\u6574\u7e3d\u6574\u7406-300x225.jpg 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2022\/01\/016-SGLT2\u6291\u5236\u5291\u814e\u529f\u80fd\u8abf\u6574\u7e3d\u6574\u7406-768x576.jpg 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2022\/01\/016-SGLT2\u6291\u5236\u5291\u814e\u529f\u80fd\u8abf\u6574\u7e3d\u6574\u7406-585x439.jpg 585w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/><figcaption class=\"wp-element-caption\">SGLT2\u6291\u5236\u5291\u814e\u529f\u80fd\u8abf\u6574\u7e3d\u6574\u7406<\/figcaption><\/figure><\/div>\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u8981\u600e\u9ebc\u770b\u9019\u5f35\u5716\u5462\uff1f<\/p>\n\n\n\n<p>\u5be6\u5fc3\u7dda\u689d\uff08\u5de6\uff09\u662f\u81fa\u7063\u4eff\u55ae\u76ee\u524d\u898f\u7bc4\uff0c\u7a7a\u5fc3\u7dda\u689d\uff08\u53f3\uff09\u662f Uptodate \u8cc7\u6599\u5eab\uff0c\u4e5f\u5c31\u662f\u7f8e\u570b\u7684\u6838\u51c6\u8cc7\u6599\u3002<\/p>\n\n\n\n<ul>\n<li><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-green-cyan-color\"><strong>\u7da0\u8272\u7dda\u689d<\/strong><\/mark>\u8868\u793a\u53ef\u4ee5\u4f7f\u7528\u3002<\/li>\n\n\n\n<li><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-luminous-vivid-amber-color\"><strong>\u9ec3\u8272\u7dda\u689d<\/strong><\/mark>\u8868\u793a\u8a72\u814e\u529f\u80fd\u5340\u57df\u4e0d\u5efa\u8b70\u8d77\u59cb\u6cbb\u7642\uff0c\u4f46\u539f\u672c\u6709\u4f7f\u7528\u8005\u5373\u4f7f\u814e\u529f\u80fd\u8b8a\u5dee\uff0c\u9084\u662f\u53ef\u4ee5\u7e7c\u7e8c\u4f7f\u7528\u3002<\/li>\n\n\n\n<li><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-red-color\"><strong>\u7d05\u8272\u7dda\u689d<\/strong><\/mark>\u8868\u793a\u4e0d\u5efa\u8b70\u6216\u7981\u5fcc\u4f7f\u7528\u3002<\/li>\n<\/ul>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u672c\u9662-sglt2-\u6291\u5236\u5291\u7a2e\u985e\"><span class=\"ez-toc-section\" id=\"%E6%9C%AC%E9%99%A2_SGLT2_%E6%8A%91%E5%88%B6%E5%8A%91%E7%A8%AE%E9%A1%9E\"><\/span><strong>\u672c\u9662 SGLT2 \u6291\u5236\u5291\u7a2e\u985e<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u76ee\u524d\u6211\u5011\u91ab\u9662\u6709\u4e09\u7a2e SGLT2 \u6291\u5236\u5291\u55ae\u65b9\uff0c\u5169\u7a2e\u5408\u4f75 metformin \u7684\u8907\u65b9\uff0c\u4e09\u7a2e\u5408\u4f75 DPP-4 \u6291\u5236\u5291\u7684\u8907\u65b9\uff0c\u7e3d\u5171 8 \u7a2e SGLT2 \u6291\u5236\u5291\u6210\u5206\u85e5\u54c1\uff0c<strong>\u8907\u65b9\u76ee\u524d\u90fd\u53ea\u6709\u62ff\u5230\u300c\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff09\u300d\u7684\u9069\u61c9\u75c7<\/strong>\uff0c\u55ae\u65b9\u5c31\u6bd4\u8f03\u4e0d\u4e00\u6a23\u4e86\u3002<\/p>\n\n\n\n<ul>\n<li><strong>Empagliflozin\uff08Jardiance\uff0c\u6069\u6392\u7cd6\uff09<\/strong>\uff0d\u53d6\u5f97\u9069\u61c9\u75c7\u5305\u542b\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3001 \u5de6\u5fc3\u5ba4\u5c04\u51fa\u5206\u7387\u4e0d\u8db3\u5fc3\u8870\u7aed\uff08HFrEF\uff09\u3001\u6b63\u5e38\u6536\u7e2e\u5206\u7387\u5fc3\u8870\u7aed\uff08HFpEF \uff09\uff0c\u4e0d\u904e HFpEF \u76ee\u524d\u81fa\u7063\u9084\u6c92\u6709\u53d6\u5f97\u9069\u61c9\u75c7\u3002<\/li>\n\n\n\n<li><strong>Dapagliflozin\uff08Forxiga\uff0c\u798f\u9069\u4f73\uff09<\/strong>\uff0d\u53d6\u5f97\u9069\u61c9\u75c7\u5305\u542b\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3001\u6162\u6027\u814e\u81df\u75be\u75c5\uff08CKD\uff09\u3001HFrEF\u3002<\/li>\n\n\n\n<li><strong>Canagliflozin\uff08Canaglu\uff0c\u53ef\u62ff\u7cd6\uff09<\/strong>\uff0d\u53d6\u5f97\u9069\u61c9\u75c7\u5305\u542b\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u548c\u7cd6\u5c3f\u75c5\u814e\u75c5\u8b8a\uff08\u5de8\u91cf\u86cb\u767d\u5c3f\u671f\uff09\u3002 <\/li>\n<\/ul>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u5f8c\u8a71\"><span class=\"ez-toc-section\" id=\"%E5%BE%8C%E8%A9%B1\"><\/span><strong>\u5f8c\u8a71<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u57fa\u672c\u4e0a\u6240\u6709\u7684 SGLT2 \u6291\u5236\u5291\u5728\u8840\u6db2\u900f\u6790\uff08hemodialysis\uff0cHD\uff09\u3001\u8179\u819c\u900f\u6790\uff08peritoneal dialysis\uff0cPD\uff09\u548c\u9023\u7e8c\u6027\u975c\u975c\u8108\u8840\u6db2\u904e\u6ffe\u8853\uff08continuous venovenous hemofiltration\uff0cCVVH\uff09\uff0c<strong><span class=\"has-inline-color has-vivid-red-color\">\u90fd\u4e0d\u5efa\u8b70\u4f7f\u7528<\/span><\/strong>\u3002<\/p>\n\n\n\n<p>SGLT2 \u6291\u5236\u5291\u8907\u65b9\u5927\u90e8\u5206\u7684\u814e\u529f\u80fd\u9650\u5236\u662f eGFR\uff1e30 \u624d\u53ef\u4ee5\u4f7f\u7528\uff0c\u9664\u4e86 Qtern \u662f\u9650\u5236 eGFR\uff1e45\u3002<\/p>\n\n\n\n<p>\u55ae\u65b9\u7684\u90e8\u5206\uff0c<strong><span class=\"has-inline-color has-vivid-red-color\">empagliflozin \u548c dapagliflozin \u90fd\u6709\u5fc3\u81df\u8870\u7aed\u65cf\u7fa4\u7684\u7814\u7a76\uff0c\u4e26\u4e14\u6536\u6848\u6642\u9ed8\u9ed8\u628a\u814e\u529f\u80fd\u5f80\u4e0b\u8abf\uff01<\/span><\/strong><\/p>\n\n\n\n<p>Empagliflozin \u653e\u5bec\u5230 eGFR\uff1e20\uff0cdapagliflozin \u653e\u5bec\u5230 eGFR\uff1e25\u3002<\/p>\n\n\n\n<p>\u6162\u6027\u814e\u81df\u75c5\u7684\u65cf\u7fa4\uff0cempagliflozin 10mg \u5df2\u7d93\u653e\u5bec\u5230\u900f\u6790\u4e0d\u80fd\u7528\uff0c\u5176\u4ed6\u814e\u529f\u80fd\u90fd\u53ef\u4ee5\u7528\u4e86\u3002<\/p>\n\n\n\n<p class=\"box\"><strong>\u5ef6\u4f38\u95b1\u8b80\uff1a<a href=\"https:\/\/tinapoint.com\/empa-kidney\/\" target=\"_blank\" data-type=\"link\" data-id=\"https:\/\/tinapoint.com\/empa-kidney\/\" rel=\"noreferrer noopener\">\u3010EMPA-KIDNEY\u3011EMPAGLIFLOZIN\u00a010MG \u5c0d CKD \u65cf\u7fa4\u6709\u826f\u597d\u5fc3\u814e\u4fdd\u8b77\u6548\u679c<\/a><\/strong><\/p>\n\n\n\n<p>\u5c31\u770b\u767e\u9748\u4f73\uff08Jardiance \u7684\u85e5\u5ee0\uff09\u548c<a href=\"https:\/\/www.astrazeneca.com\/\" target=\"_blank\" data-type=\"URL\" data-id=\"https:\/\/www.astrazeneca.com\/\" rel=\"noreferrer noopener\">\u963f\u65af\u7279\u6377\u5229\u5eb7\uff08Forxiga \u7684\u85e5\u5ee0\uff09<\/a>\u8981\u600e\u9ebc\u73a9\u4e0b\u53bb\uff5e<\/p>\n\n\n\n<p>\u6216\u8a31\u4e0d\u4e45\u7684\u5c07\u4f86\u53c8\u8981\u66f4\u65b0\u9019\u5f35\u8868\u4e86\u5427\uff08\u5606\uff09<\/p>\n\n\n\n<div style=\"height:60px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"\u76f8\u95dc\u6587\u7ae0\"><span class=\"ez-toc-section\" id=\"%E7%9B%B8%E9%97%9C%E6%96%87%E7%AB%A0\"><\/span><strong>\u76f8\u95dc\u6587\u7ae0<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/tinapoint.com\/tina014-insulin\/\"><strong>\u3010\u8b80\u66f8\u7b46\u8a18\u3011\u6ce8\u5c04\u578b\u80f0\u5cf6\u7d20\uff08INSULIN\uff09\u4f5c\u7528\u6642\u9593\u4e00\u89bd\u8868<\/strong><\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/tinapoint.com\/tina015-glp1-agonis\/\"><strong>\u3010\u8b80\u66f8\u7b46\u8a18\u3011GLP-1\u53d7\u9ad4\u4fc3\u6548\u5291\u4e00\u89bd\u8868<\/strong><\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/tinapoint.com\/r001\/\"><strong>\u3010\u6587\u737b\u5c0e\u8b80\u3011EMPAGLIFLOZIN\u964d\u4f4e\u5fc3\u81df\u8870\u7aed\u75c5\u4eba25%\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98a8\u96aa\uff0c\u4e0d\u7ba1\u6709\u7121\u7cd6\u5c3f\u75c5(EMPEROR-REDUCED)<\/strong><\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/tinapoint.com\/r003\/\"><strong>\u3010\u6587\u737b\u5c0e\u8b80\u3011\u5fc3\u81df\u8870\u7aed\u91cd\u5927\u7a81\u7834\uff01EMPAGLIFLOZIN\u53ef\u4ee5\u964d\u4f4eLVEF\uff1e40%\u65cf\u7fa4\u7684\u98a8\u96aa(EMPEROR-PRESERVED)<\/strong><\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-group box\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>\u4f60\u662f\u91ab\u9662\u85e5\u5e2b\u6216\u8b77\u7406\u5e2b\u55ce\uff1f<\/p>\n\n\n\n<p>\u6642\u5e38\u9047\u5230\u75c5\u4eba\u8981\u7d66\u8a31\u591a\u91dd\u5291\u85e5\u54c1\uff0c\u7919\u65bc\u7ba1\u8def\u4e0d\u5920\u9700\u8981\u540c\u6642\u7d66\u85e5 &#8230;&#8230;<\/p>\n\n\n\n<p>\u537b\u4e0d\u77e5\u9053\u9019\u4e9b\u85e5\u7269\u53ef\u4e0d\u53ef\u4ee5\u65c1\u63d2\u4f7f\u7528\u55ce\uff1f<\/p>\n\n\n\n<p>\u5225\u64d4\u5fc3\uff01<\/p>\n\n\n\n<p>\u5c0f\u6db5\u85e5\u5e2b\u6574\u7406\u4e86\u4f4f\u9662\u75c5\u4eba\u5e38\u7528\u7684\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\uff0c\u6b61\u8fce\u9ede\u64ca\u4e0b\u5716\u7d22\u53d6\u5594\uff01<\/p>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/subscribepage.io\/EPTKCz\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" width=\"1024\" height=\"574\" src=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-1024x574.png\" alt=\"\" class=\"wp-image-3721\" srcset=\"https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-1024x574.png 1024w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-300x168.png 300w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-768x431.png 768w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716-585x328.png 585w, https:\/\/tinapoint.com\/wp-content\/uploads\/2023\/04\/\u91dd\u5291\u76f8\u5bb9\u6027\u901f\u67e5\u8868\u5927\u5716.png 1038w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u5e02\u9762\u4e0a\u6709\u8d8a\u4f86\u8d8a\u591a\u7a2e\u7684 SGLT2 \u6291\u5236\u5291\u85e5\u54c1\uff0c\u55ae\u65b9\u52a0\u8907\u65b9\u7433\u746f\u6eff\u76ee\uff0c\u5916\u52a0\u5404\u81ea\u4e0d\u540c\u7684\u814e\u529f\u80fd\u9650\u5236\uff0c\u4f60\u80fd\u8a8d\u6e05\u55ce\uff1f\u672c\u6587\u8a73\u7d30\u6574\u7406\u4e86\u570b\u5167\u4eff\u55ae\u8207\u7f8e\u570b Uptodate \u8cc7\u6599\u5eab\u5c0d SGLT2 \u6291\u5236\u5291\u85e5\u54c1\u7684\u9069\u61c9\u75c7\u8207\u814e\u529f\u80fd\u898f\u7bc4\uff0c\u6b61\u8fce\u5927\u5bb6\u53d6\u7528\uff5e<\/p>\n","protected":false},"author":1,"featured_media":3639,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[106],"tags":[84,73,83,80,78],"table_tags":[],"modified_by":"\u5c0f\u6db5\u85e5\u5e2b","_links":{"self":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/2262"}],"collection":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/comments?post=2262"}],"version-history":[{"count":2,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/2262\/revisions"}],"predecessor-version":[{"id":4564,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/posts\/2262\/revisions\/4564"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/media\/3639"}],"wp:attachment":[{"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/media?parent=2262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/categories?post=2262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/tags?post=2262"},{"taxonomy":"table_tags","embeddable":true,"href":"https:\/\/tinapoint.com\/wp-json\/wp\/v2\/table_tags?post=2262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}